Targeting nanoparticles to malignant tissues for improved diagnosis and therapy is a
popular concept. However, after surveying the literature from the past 10 years, only …

99% of administered nanoparticles will accumulate and sequester in the liver after
administration into the body. This results in reduced delivery to the targeted diseased tissue …

Pancreatic ductal adenocarcinoma (PDAC) is a devastating metastatic disease for which
better therapies are urgently needed. Macrophages enhance metastasis in many cancer …

Senescent cells (SCs) have been considered a source of age-related chronic sterile
systemic inflammation and a target for anti-aging therapies. To understand mechanisms …

Implanted biomaterials often fail because they elicit a foreign body response (FBR) and
concomitant fibrotic encapsulation. To design clinically relevant interference approaches, it …

Non-alcoholic fatty liver disease has become the leading liver disease in North America and
is associated with the progressive inflammatory liver disease non-alcoholic steatohepatitis …

Emergence of thermogenic adipocytes such as brown and beige adipocytes is critical for
whole body energy metabolism. Promoting the emergence of these adipocytes, which …

Myeloid cells infiltrating the tumor microenvironment, especially tumor-associated
macrophages (TAMs), are essential providers of cancer-related inflammation, a condition …

Efficient clearance of bacteremia prevents life-threatening disease. Platelet binding to
intravascular bacteria, a process involving platelet glycoprotein GPIb and bacterial …

Hepatic stellate cells (HSCs) constitute the liver sinusoid with Kupffer cells and liver
sinusoidal endothelial cells. While the sinusoid functions as the gateway to liver …