Glioblastoma multiforme (GBM), an aggressive tumor that typically exhibits treatment failure
with high mortality rates, is associated with the presence of cancer stem cells (CSCs) within …

The ability to generate human induced pluripotent stem cells (iPSCs) from somatic cells
provides tremendous promises for regenerative medicine and its use has widely increased …

The human naive pluripotent stem cell (PSC) state, corresponding to a pre-implantation
stage of development, has been difficult to capture and sustain in vitro. We report that the …

It is imperative to develop organ manufacturing technologies based on the high organ failure
mortality and serious donor shortage problems. As an emerging and promising technology …

The ability to generate transplantable neural cells in a large quantity in the laboratory is a
critical step in the field of developing stem cell regenerative medicine for neural repair …

The unlimited proliferative ability and capacity to contribute to germline chimeras make
pluripotent embryonic stem cells (ESCs) perfect candidates for complex genetic …

Regenerative medicine aims to repair and regenerate injured tissues and restore their
impaired functions. Recent developments in stem cell biology have attracted significant …

Aim To investigate the expression of the renin–angiotensin system (RAS) in cancer stem
cells (CSCs), we have previously characterized in glioblastoma multiforme (GBM). Methods …

Highlights•High levels of Erk signaling promote differentiation of embryonic stem cells.•A
minimal level of Erk signaling is required for cell proliferation, cell cycle progression …

Diabetes mellitus (DM) is a widespread metabolic disease with a progressive incidence of
morbidity and mortality worldwide. Despite extensive research, treatment options for diabetic …