The next generation of therapeutics for chronic kidney disease
Chronic kidney disease (CKD) represents a leading cause of death in the United States.
There is no cure for this disease, with current treatment strategies relying on blood pressure …
There is no cure for this disease, with current treatment strategies relying on blood pressure …
Insights into kidney diseases from genome-wide association studies
M Wuttke, A Köttgen - Nature Reviews Nephrology, 2016 - nature.com
Over the past decade, genome-wide association studies (GWAS) have considerably
improved our understanding of the genetic basis of kidney function and disease. Population …
improved our understanding of the genetic basis of kidney function and disease. Population …
Developing treatments for chronic kidney disease in the 21st century
Chronic kidney disease (CKD) is a lethal and rapidly increasing burden on society. Despite
this, there are relatively few therapies in development for the treatment of CKD. Several …
this, there are relatively few therapies in development for the treatment of CKD. Several …
[HTML][HTML] Enrichment of risk SNPs in regulatory regions implicate diverse tissues in Parkinson's disease etiology
Recent genome-wide association studies (GWAS) of Parkinson's disease (PD) revealed at
least 26 risk loci, with associated single nucleotide polymorphisms (SNPs) located in non …
least 26 risk loci, with associated single nucleotide polymorphisms (SNPs) located in non …
Defining glomerular disease in mechanistic terms: implementing an integrative biology approach in nephrology
LH Mariani, WF Pendergraft III… - Clinical Journal of the …, 2016 - journals.lww.com
Advances in biomedical research allow for the capture of an unprecedented level of genetic,
molecular, and clinical information from large patient cohorts, where the quest for precision …
molecular, and clinical information from large patient cohorts, where the quest for precision …
[HTML][HTML] First report of familial juvenile hyperuricemic nephropathy (FJHN) in Iran caused by a novel de novo mutation (E197X) in UMOD
T Malakoutian, A Amouzegar, F Vali… - Journal of molecular …, 2016 - ncbi.nlm.nih.gov
Uromodulin (UMOD) gene mutation causes autosomal dominant Uromodulin-Associated
Kidney Disease (UAKD), which in turn leads to end-stage renal disease. This is the first case …
Kidney Disease (UAKD), which in turn leads to end-stage renal disease. This is the first case …
APOL1 variants: from parasites to kidney function to cardiovascular disease
AP Reiner, K Susztak - Arteriosclerosis, thrombosis, and vascular …, 2016 - Am Heart Assoc
220 Arterioscler Thromb Vasc Biol February 2016 such as CARDIoGRAM, include tens of
thousands of cases and have identified genetic risk factors for coronary heart disease in …
thousands of cases and have identified genetic risk factors for coronary heart disease in …