Executive summary Alzheimer's disease (AD) is the leading cause of dementia, and
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …

Background and Purpose—Silent brain infarction (SBI) on magnetic resonance imaging has
been proposed as a subclinical risk marker for future symptomatic stroke. We performed a …

The term cerebral small vessel disease (SVD) refers to a group of pathologic processes with
various etiologies that affect small arteries, arterioles, venules, and capillaries of the brain …

Vascular contributions to cognitive impairment are receiving heightened attention as
potentially modifiable factors for dementias of later life. These factors have now been linked …

Neurovascular dysfunction, including blood–brain barrier (BBB) breakdown and cerebral
blood flow (CBF) dysregulation and reduction, are increasingly recognized to contribute to …

Importance Cerebral microbleeds (CMBs) have been established as an independent
predictor of cerebral bleeding. There are contradictory data regarding the potential …

Importance Cerebral amyloid angiopathy (CAA) is characteristically associated with
magnetic resonance imaging (MRI) biomarkers of small vessel brain injury, including strictly …

Neuropsychiatric (NP) involvement in Systemic Lupus Erythematosus (SLE), can be a
severe and troubling manifestation of the disease that heavily impacts patient's health …

Millions of urban children are chronically exposed to high concentrations of air pollutants, ie,
fine particulate matter (PM 2.5) and ozone, associated with increased risk for Alzheimer's …

Aortic stiffness is associated with cognitive decline and cerebrovascular disease late in life,
although these associations have not been examined in young adults. Understanding the …