Obesity and diabetes mellitus have reached epidemic proportions in the past few years.
During 2011 to 2012, more than one-third of the US population was obese. Although recent …

In this volume of the IJE, Gao and colleagues explore the causal effect of adiposity on
several cancers using twosample Mendelian randomization (MR), and find some evidence …

Mendelian randomization analyses are often performed using summarized data. The causal
estimate from a one‐sample analysis (in which data are taken from a single data source) …

Long-range interactions between regulatory elements and gene promoters play key roles in
transcriptional regulation. The vast majority of interactions are uncharted, constituting a …

Objective Development of these guidelines is mandated by the American Association of
Clinical Endocrinologists (AACE) Board of Directors and the American College of …

Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the
elderly, with limited therapeutic options. Here we report on a study of> 12 million variants …

The gut microbiome is affected by multiple factors, including genetics. In this study, we
assessed the influence of host genetics on microbial species, pathways and gene ontology …

Background Pharmacologic inhibitors of proprotein convertase subtilisin–kexin type 9
(PCSK9) are being evaluated in clinical trials for the treatment of cardiovascular disease …

Many genetic variants influence complex traits by modulating gene expression, thus altering
the abundance of one or multiple proteins. Here we introduce a powerful strategy that …

Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1 …