Context: Idiopathic primary ovarian insufficiency (POI) is a major cause of amenorrhea and
infertility. POI affects 1% of women before age 40 years, and several genetic causes have …

STUDY QUESTION Does a heterozygous mutation in AMHR2, identified in whole-exome
sequencings (WES) of patients with primary ovarian insufficiency (POI), cause a defect in …

Context: Premature ovarian insufficiency (POI) may be secondary to chemotherapy,
radiotherapy, or environmental factors. Genetic causes are identified in 20–25% of cases …

Objective: The pathophysiology of primary ovarian insufficiency (POI) is not well elucidated.
Many candidate genetic aberrations are on the X-chromosome; on the contrary, many …

Premature ovarian insufficiency (POI) is a clinical syndrome defined by a loss of ovarian
activity before the age of 40. Its pathogenesis is still largely unknown, but increasing …

Premature ovarian insufficiency (POI) affects approximately 1% of women before the age of
40. Genetic contribution is a significant component of POI. In this context, heterozygous …

Bone morphogenetic protein 15 (BMP15) is a member of the transforming growth factor β
(TGFβ) super family that is expressed by oocytes and plays key roles in granulosa cell …

Primary ovarian insufficiency (POI) is a subclass of ovarian dysfunction in which the resting
pool of primordial follicles is prematurely exhausted. It occurs through two major …

Les anomalies du développement sexuel recouvrent un spectre phénotypique large. Les
hommes XX présentent dans la majorité des cas un développement testiculaire normal, lié à …

Bone morphogenetic factor 15 (BMP15) and growth differentiation factor 9 (GDF9) are two
oocyte-secreted factors with well documented effects on ovarian follicular development and …