Background and aims Bisphosphonates might be effective in reducing cardiovascular
events due to their ability to reduce calcification in arterial walls. We aimed to investigate the …

Vascular calcification (VC) represents a recognized adverse predictor for cardiovascular
morbidity and mortality. Previously considered passive and degenerative, VC is now …

Background Klotho proteins (α-and β) are membrane-based circulating proteins that
regulate cell metabolism, as well as the lifespan modulating activity of Fibroblast Growth …

Vascular disease, such as atherosclerosis and diabetic vasculopathy, is frequently
complicated by vascular calcification. Previously believed to be an end-stage process of …

Background Abdominal aortic calcification (AAC) is commonly observed in chronic dialysis
patients and is associated with cardiovascular and all-cause mortality. We investigated the …

Clear evidence supports a role for circulating and locally-produced osteocalcin (OC) in the
pathophysiology of cardiovascular (CV) lesions and CV risk, also in combination with …

Wnt/β-catenin signaling pathway is thought to be implicated in the development of arterial
stiffness and vascular calcification. As a Wnt signaling pathway inhibitor, it is interesting to …

Vascular calcification has been considered as a biological process resembling bone
formation involving osteogenic differentiation. It is a major risk factor for cardiovascular …

Chronic kidney disease, despite being a “silent epidemic” disease, represents one of the
main causes of mortality in general population, along with cardiovascular disease, which is …

Background Our previous study indicates that IL-37 plays a critical role in both
atherosclerosis and arterial calcification. However, whether IL-37 concentrations are …