The evolution of natural killer cell receptors

P Carrillo-Bustamante, C Keşmir, RJ de Boer - Immunogenetics, 2016 - Springer
Natural killer (NK) cells are immune cells that play a crucial role against viral infections and
tumors. To be tolerant against healthy tissue and simultaneously attack infected cells, the …

Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1

WF Garcia-Beltran, A Hölzemer, G Martrus… - Nature …, 2016 - nature.com
The activating natural killer (NK)-cell receptor KIR3DS1 has been linked to the outcome of
various human diseases, including delayed progression of disease caused by human …

KIR3DL1 and HLA-B density and binding calibrate NK education and response to HIV

JE Boudreau, TJ Mulrooney, JB Le Luduec… - The Journal of …, 2016 - journals.aai.org
NK cells recognize self-HLA via killer Ig-like receptors (KIR). Homeostatic HLA expression
signals for inhibition via KIR, and downregulation of HLA, a common consequence of viral …

[HTML][HTML] Activating KIR2DS4 is expressed by uterine NK cells and contributes to successful pregnancy

PR Kennedy, O Chazara, L Gardner… - The Journal of …, 2016 - journals.aai.org
Tissue-specific NK cells are abundant in the pregnant uterus and interact with invading
placental trophoblast cells that transform the maternal arteries to increase the fetoplacental …

The role of NK cells in HIV-1 protection: autologous, allogeneic or both?

J Hens, W Jennes, L Kestens - AIDS Research and Therapy, 2016 - Springer
Natural killer (NK) cells specialize in killing virally infected-or tumor cells and are part of the
innate immune system. The activational state of NK cells is determined by the balance of …

The effects of killer cell immunoglobulin-like receptor (KIR) genes on susceptibility to HIV-1 infection in the Polish population

K Zwolińska, O Błachowicz, T Tomczyk, B Knysz… - Immunogenetics, 2016 - Springer
Killer cell immunoglobulin-like receptors (KIR) are the most polymorphic receptors of natural
killer (NK) cells. Their activity diversifies the functions of NK cells in the antiviral immune …

[HTML][HTML] Natural killer cell diversity in viral infection: why and how much?

CA Blish - Pathogens & immunity, 2016 - ncbi.nlm.nih.gov
Natural killer cells are a diverse group of innate lymphocytes that are specialized to rapidly
respond to cancerous or virus-infected cells. NK cell function is controlled by the integration …

[HTML][HTML] The role genes encoding of killer cell immunoglobulin-like receptors (KIRs) and their ligands in susceptibility to and progression of HIV infection

O Błachowicz, K Zwolińska - Advances in Hygiene and Experimental …, 2016 - phmd.pl
NK cells are a part of the innate antiviral response. Their activity is regulated by signals from
the surface receptors. Some of them, known as killer cell immunoglobulin-like receptors …

[HTML][HTML] Rola genów kodujących immunoglobulinopodobne receptory komórek cytotoksycznych (KIR) oraz ich ligandy w podatności i przebiegu zakażenia HIV

O Błachowicz, K Zwolińska - Postępy Higieny i Medycyny Doświadczalnej, 2016 - phmd.pl
Komórki NK stanowią element nieswoistej odpowiedzi przeciwwirusowej, a ich aktywność
jest regulowana przez sygnały wysyłane przez receptory na ich powierzchni. Należą do nich …

Discovery and characterization of the ligands of NK-cell receptors implicated in human diseases

WF Garcia Beltran - 2016 - dash.harvard.edu
Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that act as
first-line defenders against intracellular pathogens. Their functions are dictated by germline …