The GATA family of transcription factors consists of six proteins (GATA1-6) which are
involved in a variety of physiological and pathological processes. GATA1/2/3 are required …

The activities of the heterogeneous Polycomb (PcG) group of proteins ensure that the
developmental processes of proliferation and cellular identity establishment are carried out …

The MDM2 oncoprotein ubiquitinates and antagonizes p53 but may also carry out p53-
independent functions. Here we report that MDM2 is required for the efficient generation of …

Binding of the transcriptional co-activator YAP with the transcription factor TEAD stimulates
growth of the heart and other organs. YAP overexpression potently stimulates fetal …

Direct conversion of fibroblasts into induced cardiomyocytes (iCMs) offers an alternative
strategy for cardiac disease modeling and regeneration. During iCM reprogramming, the …

Background & Aims The embryonic small intestinal epithelium is highly proliferative, and
although much is known about mechanisms regulating proliferation in the adult intestine, the …

Overexpression of EZH2 is frequently linked to the advanced and metastatic stage of
cancers. The mechanisms of its oncogenic function can be context specific, and may vary …

Heart failure is a leading cause of cardiovascular mortality in industrialized countries. During
development and deterioration of heart failure, cardiomyocytes undergo maladaptive …

Polycomb group (PcG) proteins are transcriptional repressors of numerous genes, many of
which regulate cell cycle progression or developmental processes. We used zebrafish to …

Polycomb group proteins represent a global silencing system involved in development
regulation. In specific, they regulate the transition from proliferation to differentiation …