Obesity statistics
KB Smith, MS Smith - Primary care: clinics in office …, 2016 - primarycare.theclinics.com
Obesity is a complex, multifactorial disease that is strongly associated with multiple
comorbidities. 1–6 These comorbidities include certain types of cancer, cardiovascular …
comorbidities. 1–6 These comorbidities include certain types of cancer, cardiovascular …
Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity
In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …
cause of numerous health complications and increased mortality. Being a complex and …
American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with …
WT Garvey, JI Mechanick, EM Brett, AJ Garber… - Endocrine Practice, 2016 - Elsevier
Objective Development of these guidelines is mandated by the American Association of
Clinical Endocrinologists (AACE) Board of Directors and the American College of …
Clinical Endocrinologists (AACE) Board of Directors and the American College of …
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the
elderly, with limited therapeutic options. Here we report on a study of> 12 million variants …
elderly, with limited therapeutic options. Here we report on a study of> 12 million variants …
[HTML][HTML] Genotype imputation with millions of reference samples
BL Browning, SR Browning - The American Journal of Human Genetics, 2016 - cell.com
We present a genotype imputation method that scales to millions of reference samples. The
imputation method, based on the Li and Stephens model and implemented in Beagle v. 4.1 …
imputation method, based on the Li and Stephens model and implemented in Beagle v. 4.1 …
[HTML][HTML] Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Reduced glomerular filtration rate defines chronic kidney disease and is associated with
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …
Selecting instruments for Mendelian randomization in the wake of genome-wide association studies
DI Swerdlow, KB Kuchenbaecker… - International journal …, 2016 - academic.oup.com
Mendelian randomization (MR) studies typically assess the pathogenic relevance of
environmental exposures or disease biomarkers, using genetic variants that instrument …
environmental exposures or disease biomarkers, using genetic variants that instrument …
Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases
Mapping perturbed molecular circuits that underlie complex diseases remains a great
challenge. We developed a comprehensive resource of 394 cell type–and tissue-specific …
challenge. We developed a comprehensive resource of 394 cell type–and tissue-specific …
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index
JF Felix, JP Bradfield, C Monnereau… - Human molecular …, 2016 - academic.oup.com
A large number of genetic loci are associated with adult body mass index. However, the
genetics of childhood body mass index are largely unknown. We performed a meta-analysis …
genetics of childhood body mass index are largely unknown. We performed a meta-analysis …
A thrifty variant in CREBRF strongly influences body mass index in Samoans
Samoans are a unique founder population with a high prevalence of obesity,,, making them
well suited for identifying new genetic contributors to obesity. We conducted a genome-wide …
well suited for identifying new genetic contributors to obesity. We conducted a genome-wide …