Endothelin
The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1
and-2 activate two G-protein coupled receptors, ETA and ETB, with equal affinity, whereas …
and-2 activate two G-protein coupled receptors, ETA and ETB, with equal affinity, whereas …
From bosentan (Tracleer®) to macitentan (Opsumit®): The medicinal chemistry perspective
C Boss, MH Bolli, J Gatfield - Bioorganic & Medicinal Chemistry Letters, 2016 - Elsevier
The endothelin peptides bind to two receptors found on cells of vasculature and in tissues.
While the endothelin-A (ETA)-receptor is predominantly expressed in vascular smooth …
While the endothelin-A (ETA)-receptor is predominantly expressed in vascular smooth …
EdnrB governs regenerative response of melanocyte stem cells by crosstalk with Wnt signaling
Delineating the crosstalk between distinct signaling pathways is key to understanding the
diverse and dynamic responses of adult stem cells during tissue regeneration. Here, we …
diverse and dynamic responses of adult stem cells during tissue regeneration. Here, we …
Serum concentrations of endothelin-1 and matrix metalloproteinases-2,-9 in pre-hypertensive and hypertensive patients with type 2 diabetes
Endothelin-1 (ET-1) is one of the most potent vasoconstrictors known to date. While its
plasma or serum concentrations are elevated in some forms of experimental and human …
plasma or serum concentrations are elevated in some forms of experimental and human …
[HTML][HTML] Global overexpression of ET-1 decreases blood pressure-A systematic review and meta-analysis of ET-1 transgenic mice
YP Lu, O Tsuprykov, N Vignon-Zellweger… - Kidney and Blood …, 2016 - karger.com
Background/Aims: ET-1 has independent effects on blood pressure regulation in vivo, it is
involved in tubular water and salt excretion, promotes constriction of smooth muscle cells …
involved in tubular water and salt excretion, promotes constriction of smooth muscle cells …
The effect of sorafenib, tadalafil and macitentan treatments on thyroxin-induced hemodynamic changes and cardiac abnormalities
Multikinase inhibitors (eg Sorafenib), phosphodiesterase-5 inhibitors (eg Tadalafil), and
endothelin-1 receptor blockers (eg Macitentan) exert influential protection in a variety of …
endothelin-1 receptor blockers (eg Macitentan) exert influential protection in a variety of …
Značaj markera endotelne disfunkcije, oksidativnog stresa i inflamacije u dvogodišnjoj prognozi kod bolesnika sa akutnim infarktom miokarda
DM Stanojević - Универзитет у Нишу, 2016 - nardus.mpn.gov.rs
Predmet: Stručna ocena i mišljenje o izradjenoj doktorskoj disertaciji dr Dragane Stanojević
Odlukom Nastavno-naučnog veća Medicinskog fakulteta u Nišu, prihvaćen je izveštaj …
Odlukom Nastavno-naučnog veća Medicinskog fakulteta u Nišu, prihvaćen je izveštaj …
The Impact of Weight Fluctuation on Atrial Substrate and the Prevention of Atrial Remodelling With the Use of Anti-Fibrotics
DJ Twomey - 2016 - digital.library.adelaide.edu.au
Atrial fibrillation (AF) is the commonest sustained arrhythmia in humans and is responsible
for a significant socioeconomic burden. Affected individuals can suffer significant symptoms …
for a significant socioeconomic burden. Affected individuals can suffer significant symptoms …