Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …

Traumatic brain injuries (TBIs) are clinically grouped by severity: mild, moderate and severe.
Mild TBI (the least severe form) is synonymous with concussion and is typically caused by …

Traditionally seen as a sudden, brutal event with short-term impairment, traumatic brain
injury (TBI) may cause persistent, sometimes life-long, consequences. While mortality after …

Traumatic axonal injury (TAI) is an important pathoanatomical subgroup of traumatic brain
injury (TBI) and a major driver of mortality and functional impairment. Experimental models …

Traumatic brain injury (TBI) is a leading cause of mortality and morbidity worldwide.
Neuroinflammation is prominent in the short and long-term consequences of neuronal …

The chronic effects of repetitive head impacts (RHI) on the development of
neuroinflammation and its relationship to chronic traumatic encephalopathy (CTE) are …

Targeted drugs have changed cancer treatment but are often ineffective in the long term
against solid tumours, largely because of the activation of heterogeneous oncogenic …

Melatonin functions as a crucial mediator of sterile neuroinflammation; however, the
underlying mechanisms remain poorly understood. Dysfunctional mitochondria, a main …

Background: Chronic traumatic encephalopathy (CTE) is a tauopathy associated with prior
exposure to repetitive head impacts, such as those incurred through American football and …

Exposure to repetitive mild traumatic brain injury (mTBI) is a risk factor for chronic traumatic
encephalopathy, which is characterized by patchy deposition of hyperphosphorylated tau …