Age-related macular degeneration (AMD) is a major cause of irreversible blindness affecting
elderly people in the world. AMD is a complex multifactorial disease associated with …

Maternal diabetes mellitus is a significant risk factor for structural birth defects, including
congenital heart defects and neural tube defects. With the rising prevalence of type 2 …

The main characteristic of senescence is its stability which relies on the persistence of DNA
damage. We show that unlike fibroblasts, senescent epithelial cells do not activate an ATM …

The proliferation, migration and inflammation of vascular smooth muscle cells (VSMCs)
contribute to the pathogenesis and progression of several cardiovascular diseases such as …

Oncogenic transformation may reprogram tumor metabolism and render cancer cells
addicted to extracellular nutrients. Deprivation of these nutrients may therefore represent a …

Highly pathogenic H5N1 infections are often accompanied by excessive pro-inflammatory
response, high viral titer, and apoptosis; as such, the efficient control of these infections …

The anti-cancer effects of dioscin have been widely reported. However, its effect on
laryngeal cancer remains unknown. In the present paper, our results showed that dioscin …

Biglycan, a ubiquitous proteoglycan, acts as a danger signal when released from the
extracellular matrix. As such, biglycan triggers the synthesis and maturation of interleukin-1β …

Oxidative stress and inflammatory responses have been identified as key elements of
neuronal cell apoptosis. In this study, we investigated the mechanisms by which …

Isoalantolactone possessed various biological activities. However, whether it could treat
breast cancer and its underlying mechanism remained largely unknown. This study was …