Genetic abnormalities in the DNA repair genes BRCA1 and BRCA2 predispose to hereditary
breast and ovarian cancer (HBOC). However, only approximately 25% of cases of HBOC …

Eukaryotic cells respond to DNA damage by activating a comprehensive network of
biochemical pathways that enable damage recognition and initiate responses leading to …

The Fanconi anemia (FA) pathway plays a central role in the repair of DNA interstrand
crosslinks (ICL s) and regulates cellular responses to replication stress. Homologous …

Although RNA and RNA-binding proteins have been linked to double-strand breaks (DSBs),
little is known regarding their roles in the cellular response to DSBs and, if any, in the repair …

Regional hyperthermia is described as a targeted therapy and the definitions of six
hallmarks of hyperthermia are proposed, representing the pleiotropic effect of this …

Genetic abnormalities are present in all tumor types, although the frequency and type can
vary. Chromosome abnormalities include highly aberrant structures, particularly …

DNA damage activates the ATM and ATR kinases that coordinate checkpoint and DNA
repair pathways. An essential step in homology‐directed repair (HDR) of DNA breaks is the …

BRCA2 is a multi-faceted protein critical for the proper regulation of homology-directed
repair of DNA double-strand breaks. Elucidating the mechanistic features of BRCA2 is …

The UAF1-USP1 complex deubiquitinates FANCD2 during execution of the Fanconi anemia
DNA damage response pathway. As such, UAF1 depletion results in persistent FANCD2 …

Human breast cancer susceptibility gene, BRCA2, encodes a 3418-amino acid protein that
is essential for maintaining genomic integrity. Among the proteins that physically interact …