V Regitz-Zagrosek, G Kararigas - Physiological reviews, 2016 - journals.physiology.org
Major differences between men and women exist in epidemiology, manifestation, pathophysiology, treatment, and outcome of cardiovascular diseases (CVD), such as …
Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, with limited therapeutic options. Here we report on a study of> 12 million variants …
Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals 1 …
Mendelian randomization studies are often performed in an instrumental variables framework, using germline genetic variants as instruments for modifiable disease risk factors …
We performed a scan for genetic variants associated with multiple phenotypes by comparing large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 …
Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with human complex traits. However, the genes or functional DNA elements …
DA Lawlor - International journal of epidemiology, 2016 - academic.oup.com
In this volume of the IJE, Gao and colleagues explore the causal effect of adiposity on several cancers using twosample Mendelian randomization (MR), and find some evidence …
Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a …
In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying cause of numerous health complications and increased mortality. Being a complex and …