The pathogenesis of frailty and the role of inflammation is poorly understood. We examined
the evidence considering the relationship between inflammation and frailty through a …

Background In the elderly, chronic low-grade inflammation (inflammaging) is a risk factor for
the development of aging-related diseases and frailty. Using data from several thousand …

Senescent cells (SCs) have been considered a source of age-related chronic sterile
systemic inflammation and a target for anti-aging therapies. To understand mechanisms …

Background Assessment of operative risk in geriatric patients undergoing emergency
general surgery (EGS) is challenging. Frailty is an established measure for risk assessment …

The ethical, logistical, and biological complications of working with an older population of
people inherently limits clinical studies of frailty. The recent development of animal models …

Cardiovascular disease and frailty frequently occur together. Both are associated with
inflammation, which may be partially triggered by oxidative stress, especially in …

As Canada's population ages, frailty–with its increased risk of functional decline,
deterioration in health status, and death–will become increasingly common. The physiology …

Background: abnormal laboratory test results accumulate with age and can be common in
people with few clinically detectable health deficits. A frailty index (FI) based entirely on …

Frailty was introduced to explain why people of the same age have varying degrees of risk.
The deficit accumulation approach shows that as people age, they accumulate health …

Chronic systematic inflammation and reduced immune system fitness are considered
potential contributing factors to the development of age-related frailty, but the underlying …