Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …

Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …

During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …

Loss of cellular homeostasis during aging results in altered tissue functions and leads to a
general decline in fitness and, ultimately, death. As animals age, the control of gene …

Highlights•Genome wide distribution and function of H3K4, K27, K36me in plant and
animal.•Summary of histone lysine methylation writer, eraser and reader in plant and …

In this paper we present cellular senescence as the ultimate driver of the aging process, as a
“causal nexus” that bridges microscopic subcellular damage with the phenotypic …

Old age is associated with a progressive decline of mitochondrial function and changes in
nuclear chromatin. However, little is known about how metabolic activity and epigenetic …

Maintenance of a regular chromatin structure over the coding regions of genes occurs co-
transcriptionally via the 'chromatin resetting'pathway. One of the central players in this …

Methylation at histone 3, lysine 36 (H3K36) is a conserved epigenetic mark regulating gene
transcription, alternative splicing and DNA repair. Genes encoding H3K36 …

Abstract Changes in histone modifications are an attractive model through which
environmental signals, such as diet, could be integrated in the cell for regulating its lifespan …