A characteristic of many neurodegenerative diseases, including Alzheimer's disease (AD),
Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis …

Frontotemporal lobar degeneration (FTLD) comprises a highly heterogeneous group of
disorders clinically associated with behavioral and personality changes, language …

Pathological expansion of a G 4 C 2 repeat, located in the 5'regulatory region of C9orf72, is
the most common genetic cause of frontotemporal lobar degeneration (FTLD) and …

Hexanucleotide expansion in an intron of the C9orf72 gene causes amyotrophic lateral
sclerosis and frontotemporal dementia. However, beyond bioinformatics predictions that …

Disruptions to genes linked to RNA processing and homeostasis are implicated in the
pathogenesis of two pathologically related but clinically heterogeneous neurodegenerative …

Growing evidence implicates impairment of autophagy as a candidate pathogenic
mechanism in the spectrum of neurodegenerative disorders which includes amyotrophic …

Objective: To determine the prevalence of autoimmune disease in symptomatic C9ORF72
(C9) mutation carriers and frontotemporal dementia with motor neuron disease (FTD/MND) …

Mounting evidence indicates that the lysosome-autophagy pathway plays a critical role in
iron release from ferritin, the main iron storage cellular protein, hence in the distribution of …

Abstract Background Neuroprotection for Parkinson's disease (PD) remains elusive.
Biomarkers hold the promise of removing roadblocks to therapy development. The National …

Introduction Reliable cerebrospinal fluid (CSF) biomarkers enabling identification of
frontotemporal dementia (FTD) and its pathologic subtypes are lacking. Methods Unbiased …