Gastric cancer is one of the leading causes of cancer-related death worldwide. Many
patients have inoperable disease at diagnosis or have recurrent disease after resection with …

It is more than 50 years since the Epstein–Barr virus (EBV), the first human tumour virus, was
discovered. EBV has subsequently been found to be associated with a diverse range of …

Almost one million (951 600) new cases of gastric cancer were diagnosed globally in 2012,
resulting in∼ 723 100 deaths [1]. Of these∼ 140 000 cases and∼ 107 000 deaths occurred …

Abstract The Cancer Genome Atlas (TCGA) research network has made public a large
collection of clinical and molecular phenotypes of more than 10 000 tumor patients across …

Summary Background Expression of PD-L1 has been shown to be upregulated in some
patients with gastric cancer. As part of the phase 1b KEYNOTE-012 study, we aimed to …

Results The entire database incorporates 1,065 gastric carcinoma samples, gene
expression data. Out of 29 established markers, higher expression of BECN1 (HR= 0.68, p …

Initial results by Le and colleagues, which were published in the June 25, 2015 issue of the
New England Journal of Medicine, report significant responses of cancers with microsatellite …

Context: ERBB2 (erb-b2 receptor tyrosine kinase 2 or HER2) is currently the only biomarker
established for selection of a specific therapy for patients with advanced gastroesophageal …

Background Papillary renal-cell carcinoma, which accounts for 15 to 20% of renal-cell
carcinomas, is a heterogeneous disease that consists of various types of renal cancer …

Successful treatment of many patients with advanced cancer using antibodies against
programmed cell death 1 (PD-1; also known as PDCD1) and its ligand (PD-L1; also known …