Intellectual disability encompasses a large set of neurodevelopmental disorders of cognition
that are more common in males than females. Although mutations in over 100 X-linked …

Small activating RNAs (saRNAs) targeting specific promoter regions are able to stimulate
gene expression at the transcriptional level, a phenomenon known as RNA activation …

The PAF complex (Paf1C) has been shown to regulate chromatin modifications, gene
transcription, and RNA polymerase II (PolII) elongation. Here, we provide the first genome …

Despite their canonical two-fold symmetry, nucleosomes in biological contexts are often
asymmetric: functionalized with post-translational modifications (PTMs), substituted with …

RNA polymerase II (RNAPII) undergoes structural changes during the transitions from
initiation, elongation, and termination, which are aided by a collection of proteins called …

Influenza A virus requires ongoing cellular transcription to carry out the cap-snatching
process. Chromatin remodelers modify chromatin structure to produce an active or inactive …

Using affinity purification MS approaches, we have identified a novel role for casein kinase II
(CKII) in the modification of the polymerase associated factor complex (PAF-C). Our data …

Conserved from yeast to humans, the Paf1 complex participates in a number of diverse
processes including transcriptional initiation and polyadenylation. This complex typically …

The filamentous fungus Aspergillus flavus is an agriculturally important opportunistic plant
pathogen that produces potent carcinogenic compounds called aflatoxins. We identified the …

Histone modification is a critical determinant of the frequency and location of meiotic double-
strand breaks (DSBs), and thus recombination. Set1-dependent histone H3K4 methylation …