To maintain protein homeostasis, AAA+ proteolytic machines degrade damaged and
unneeded proteins in bacteria, archaea and eukaryotes. This process involves the ATP …

Tuberculosis (TB) is a serious and potentially fatal disease caused by Mycobacterium
tuberculosis (M. tb). The occurrence of multidrug-resistant (MDR) and extensively drug …

The Clp protease complex in Mycobacterium tuberculosis is unusual in its composition,
functional importance and activation mechanism. Whilst most bacterial species contain a …

An efficient synthetic protocol for the stereoselective synthesis of cyclomarin A is reported.
Key steps in the syntheses of the building blocks are an asymmetric chelate–enolate …

New methods are urgently needed to find novel natural products as structural leads for the
development of new drugs against emerging diseases such as cancer and multiresistant …

The Clp chaperone-protease is an essential protein quality control machine in the
pathogenic bacterium Mycobacterium tuberculosis (Mtb) that additionally performs …