Inflammasomes are multi-protein signaling complexes that trigger the activation of
inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome …

Over the past decade, numerous advances have been made in the role and regulation of
inflammasomes during pathogenic and sterile insults. An inflammasome complex comprises …

Oxidative stress reflects an imbalance between the overproduction and incorporation of free
radicals and the dynamic ability of a biosystem to detoxify reactive intermediates. Free …

Significance: A common link between all forms of acute and chronic kidney injuries,
regardless of species, is enhanced generation of reactive oxygen species (ROS) and …

High heterogeneity of macrophage is associated with its functions in polarization to different
functional phenotypes depending on environmental cues. Macrophages remain in balanced …

The high energy demand of the brain renders it sensitive to changes in energy fuel supply
and mitochondrial function. Deficits in glucose availability and mitochondrial function are …

The notion that electrophiles serve as messengers in cell signaling is now widely accepted.
Nonetheless, major issues restrain acceptance of redox homeostasis and redox signaling as …

Over the last few decades, many different groups have been engaged in studies of new
roles for mitochondria, particularly the coupling of alterations in the redox pathway with the …

Diabetic nephropathy (DN) is a serious complication of diabetes mellitus, and persistent
inflammation in circulatory and renal tissues is an important pathophysiological basis for DN …

The NLRP3 inflammasome is activated by a variety of external or host-derived stimuli and its
activation initiates an inflammatory response through caspase-1 activation, resulting in …