Crohn's disease and ulcerative colitis are prototypical complex diseases characterized by
chronic and heterogeneous manifestations, induced by interacting environmental, genomic …

Many prescriptions of traditional medicines (TMs), whose efficacy has been tested in clinical
practice, have great therapeutic value and represent an excellent resource for drug …

PRACTALL is a joint initiative of the American Academy of Allergy, Asthma & Immunology
and the European Academy of Allergy and Clinical Immunology to provide shared evidence …

A potentially useful approach for drug discovery is to connect gene expression profiles of
disease-affected tissues (“disease signatures”) to drug signatures, but it remains to be …

Phosphatidylethanolamine (PE) is the second most abundant phospholipid in mammalian
cells. PE comprises about 15–25% of the total lipid in mammalian cells; it is enriched in the …

The lack of high-throughput methods to analyze the adipose tissue protein composition
limits our understanding of the protein networks responsible for age and diet related …

A major challenge in inflammatory bowel disease (IBD) is the integration of diverse IBD data
sets to construct predictive models of IBD. We present a predictive model of the immune …

In addition to the immune system's traditional roles of conferring anti-infectious and anti-
neoplastic protection, it has been recently implicated in the regulation of systemic metabolic …

Background Single nucleotide polymorphism (SNP) arrays for domestic cattle have
catalyzed the identification of genetic markers associated with complex traits for inclusion in …

Rationale: Changes in the respiratory microbiome are associated with disease progression
in idiopathic pulmonary fibrosis (IPF). The role of the host response to the respiratory …