Cancer stem cells (CSCs), which have the potential for self-renewal, differentiation and de-
differentiation, undergo epigenetic, epithelial-mesenchymal, immunological and metabolic …

It is well established that cells sense chemical signals from their local microenvironment and
transduce them to the nucleus to regulate gene expression programmes. Although a number …

YAP is a mechanosensitive transcriptional activator with a critical role in cancer,
regeneration, and organ size control. Here, we show that force applied to the nucleus …

Increased matrix rigidity associated with the fibrotic reaction is documented to stimulate
intracellular signalling pathways that promote cancer cell survival and tumour growth …

Liver cancer is the second leading cause of cancer mortality worldwide, causing more than
700,000 deaths annually. Because of the wide landscape of genomic alterations and limited …

In plants, the photosynthetic machinery photosystem II (PSII) consists of a core complex
associated with variable numbers of light-harvesting complexes II (LHCIIs). The …

The spacing of hair in mammals and feathers in birds is one of the most apparent
morphological features of the skin. This pattern arises when uniform fields of progenitor cells …

Biomechanical and biochemical cues within a tissue collaborate across length scales to
direct cell fate during development and are critical for the maintenance of tissue …

The surrounding microenvironment limits tumour expansion, imposing a compressive stress
on the tumour, but little is known how pressure propagates inside the tumour. Here we …

During animal development, cell-fate-specific changes in gene expression can modify the
material properties of a tissue and drive tissue morphogenesis. While mechanistic insights …