Background: Studies have shown that left stellate ganglion (LSG) suppression protects
against ventricular arrhythmias (VAs). Optogenetics is a novel technique to reversibly …

A number of animal models have been designed in order to unravel the underlying
mechanisms of acute ischemia-induced arrhythmias and to test compounds and …

Rationale: Phosphodiesterase 2 is a dual substrate esterase, which has the unique property
to be stimulated by cGMP, but primarily hydrolyzes cAMP. Myocardial phosphodiesterase 2 …

Background—Considerable evidence suggests that calcium/calmodulin-dependent protein
kinase II (CaMKII) overactivity plays a crucial role in the pathophysiology of heart failure …

Preventive and/or therapeutic interventions for ischemic heart disease have gained
considerable attention worldwide. We investigated the mechanism (s) underlying …

MiRNA-1 may participate in regulating ischemia–reperfusion injury (IRI) by affecting the
expression and distribution of connexin 43 (Cx43). The aim of this study is to investigate miR …

Metabolic syndrome (MS) increases cardiovascular risk and is associated with cardiac
dysfunction and arrhythmias, although the precise mechanisms are still under study. Chronic …

In the ischemic-reperfused (I/R) heart, renin-containing mast cells (MC) release
enzymatically active renin, activating a local renin-angiotensin system (RAS), causing …

Acute myocardial infarction (AMI) with development of ventricular fibrillation (VF) is a
common cause of sudden cardiac death (SCD). At present, no pharmacological treatment …

Left stellate ganglion (LSG) hyperactivity promotes ischemia induced ventricular arrhythmia
(VA). Blocking the Nav1. 8 channel decreases neuron activity. Therefore, the present study …