In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Imbalances between excitation and inhibition in synaptic transmission and neural circuits
have been implicated in autism spectrum disorders. Excitation and inhibition imbalances are …

Using a genetic mouse model that faithfully recapitulates a DISC1 genetic alteration strongly
associated with schizophrenia and other psychiatric disorders, we examined the impact of …

Hippocampal function is important for learning and memory, and dysfunction of the
hippocampus has been linked to the pathophysiology of neuropsychiatric diseases such as …

Accumulation of amyloid β (Aβ) induces neuronal, synaptic, and cognitive deficits in patients
and animal models of Alzheimer's disease (AD). The underlying mechanisms, however …

Parvalbumin (PV) interneurons are critically involved in the cognitive processes. Based on
prior investigations that environmental enrichment reverses impaired cognition after …

Previous studies have shown that the neuregulin 1 (NRG1)-ErbB4 signaling pathway may
regulate the excitability of fast-spiking neurons in the frontal cortex and participate in primary …

Parvalbumin-expressing interneurons are pivotal for the processing of information in healthy
brain, whereas the coordination of these functions is seriously disrupted in diseased brain …

Medium spiny neurons (MSNs), the major GABAergic projection neurons in the striatum, are
implicated in many neuropsychiatric diseases such as schizophrenia, but the underlying …

Copy number variations (CNVs) have recently drawn attention as an important genetic factor
for diseases, especially common neuropsychiatric disorders including Alzheimer's disease …