Exploitation of EP300 and CREBBP lysine acetyltransferases by cancer
N Attar, SK Kurdistani - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
p300 and CREB-binding protein (CBP), two homologous lysine acetyltransferases in
metazoans, have a myriad of cellular functions. They exert their influence mainly through …
metazoans, have a myriad of cellular functions. They exert their influence mainly through …
[HTML][HTML] Acetylation-and methylation-related epigenetic proteins in the context of their targets
The nucleosome surface is covered with multiple modifications that are perpetuated by eight
different classes of enzymes. These enzymes modify specific target sites both on DNA and …
different classes of enzymes. These enzymes modify specific target sites both on DNA and …
Terminally modified RNA
T Chakraborty, S Bancel, SG Hoge, A Roy… - US Patent …, 2017 - Google Patents
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Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors
NJ Porter, A Mahendran, R Breslow… - Proceedings of the …, 2017 - National Acad Sciences
Histone deacetylases (HDACs) regulate myriad cellular processes by catalyzing the
hydrolysis of acetyl–l-lysine residues in histone and nonhistone proteins. The Zn2+ …
hydrolysis of acetyl–l-lysine residues in histone and nonhistone proteins. The Zn2+ …
Delivery and formulation of engineered nucleic acids
A De Fougerolles, SM Elbashir - US Patent 9,533,047, 2017 - Google Patents
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[HTML][HTML] Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate
CK Huang, PH Chang, WH Kuo, CL Chen… - Nature …, 2017 - nature.com
Adipocytes are the most abundant stromal partners in breast tissue. However, the crosstalk
between breast cancer cells and adipocytes has been given less attention compared to …
between breast cancer cells and adipocytes has been given less attention compared to …
Engineered nucleic acids and methods of use thereof
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Modified polynucleotides encoding hepatitis A virus cellular receptor 2
S Bancel, T Chakraborty, A De Fougerolles… - US Patent …, 2017 - Google Patents
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Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
S Bancel, T Chakraborty, A De Fougerolles… - US Patent …, 2017 - Google Patents
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Histone methylase MLL1 coordinates with HIF and regulate lncRNA HOTAIR expression under hypoxia
Hypoxia signaling plays a critical role in tumor growth, angiogenesis, metastasis cancer, and
aging. Under hypoxia, hypoxia-inducible factors (HIFs) are stabilized and they coordinate …
aging. Under hypoxia, hypoxia-inducible factors (HIFs) are stabilized and they coordinate …