The antioxidant effects of resveratrol (3, 5, 4'‐trihydroxy‐trans‐stilbene) contribute
substantially to the health benefits of this compound. Resveratrol has been shown to be a …

Fatty liver diseases, which are commonly associated with high-fat/calorie diet, heavy alcohol
consumption and/or other metabolic disorder causes, lead to serious medical concerns …

The vascular endothelium is a layer of cells lining the inner surface of vessels, serving as a
barrier that mediates microenvironment homeostasis. Deterioration of either the structure or …

Here, we review three sets of key proteins and their corresponding downstream pathways
that have been linked to extending lifespan and promoting health span in a wide range of …

The rapid growth of an aging population creates challenges regarding age-related diseases,
including AKI, for which both the prevalence and death rate increase with age. The …

Life as we know it cannot exist without the nucleotide nicotinamide adenine dinucleotide
(NAD). From the simplest organism, such as bacteria, to the most complex multicellular …

Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia. The disease
results from the defects of insulin secretion and/or action. Resveratrol is a non-flavonoid …

Insulin resistance precedes and predicts the onset of type 2 diabetes (T2D) in susceptible
humans, underscoring its important role in the complex pathogenesis of this disease. Insulin …

Accumulation of amyloid-β (Aβ) correlates significantly with progressive cognitive deficits, a
main symptom of Alzheimer's disease (AD). Although treadmill exercise reduces Aβ levels …

Mitochondria are highly dynamic and semi-autonomous organelles, essential for many
fundamental cellular processes, including energy production, metabolite synthesis, ion …