The search for reliable indicators of biological age, rather than chronological age, has been
ongoing for over three decades, and until recently, largely without success. Advances in the …

Aging is the inevitable time-dependent decline in physiological organ function and is a
major risk factor for cancer development. Due to advances in health care, hygiene control …

Behavioral and lifestyle factors have been shown to relate to a number of health-related
outcomes, yet there is a need for studies that examine their relationship to molecular aging …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

The DNA methylation levels of certain CpG sites are thought to reflect the pace of human
aging. Here, we developed a robust predictor of mouse biological age based on 90 CpG …

Background DNA methylation changes at a discrete set of sites in the human genome are
predictive of chronological and biological age. However, it is not known whether these …

Low socioeconomic status (SES) is associated with earlier onset of age-related chronic
conditions and reduced life-expectancy, but the underlying biomolecular mechanisms …

Aging is a multifactorial process characterized by the progressive loss of physiological
functions, leading to an increased vulnerability to age‐associated diseases and finally to …

Individuals suffering from Werner syndrome (WS) exhibit many clinical signs of accelerated
aging. While the underlying constitutional mutation leads to accelerated rates of DNA …

Aim of the study A vast majority of human malignancies are associated with ageing, and age
is a strong predictor of cancer risk. Recently, DNA methylation-based marker of ageing …