Psoriasis is a complex chronic inflammatory cutaneous disorder. To date, robust molecular
mechanisms of psoriasis have been reported. Among diverse aberrant immunopathogenetic …

Importance The causal direction and magnitude of the association between telomere length
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …

Infectious diseases have a profound impact on our health and many studies suggest that
host genetics play a major role in the pathogenesis of most of them. We perform 23 genome …

Psoriasis is a complex disease of skin with a prevalence of about 2%. We conducted the
largest meta-analysis of genome-wide association studies (GWAS) for psoriasis to date …

Chronic immune-mediated disorders (IMDs) constitute a major health burden.
Understanding IMD pathogenesis is facing two major constraints: Missing heritability …

Primary biliary cholangitis (PBC) is an autoimmune liver disease with a strong hereditary
component. Here, we report a genome-wide association study that included 1,122 PBC …

Background The effectiveness of biologics for psoriasis shows heterogeneity among
patients. With pharmacogenetic markers, it might be possible to predict treatment response …

HLA-C* 06: 02 is the main psoriasis risk allele. By the unbiased analysis of a Vα3S1/Vβ13S1
T-cell receptor from pathogenic psoriatic CD8+ T cells, we had recently proven that HLA-C …

Fatigue, a highly prevalent and distressing symptom during chemotherapy (CTX),
demonstrates diurnal and interindividual variability in severity. Little is known about the …

RNA‐seq has enabled in‐depth analysis of the pathogenesis of psoriasis on the
transcriptomic level, and many biomarkers have been discovered to be related to the …