Microglia emerge as central players in brain disease

MW Salter, B Stevens - Nature medicine, 2017 - nature.com
There has been an explosion of new findings recently giving us insights into the involvement
of microglia in central nervous system (CNS) disorders. A host of new molecular tools and …

Alternative splicing as a regulator of development and tissue identity

FE Baralle, J Giudice - Nature reviews Molecular cell biology, 2017 - nature.com
Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate
vast protein diversity from a limited number of genes. The mechanisms and outcomes of …

The changing epidemiology of autism spectrum disorders

K Lyall, L Croen, J Daniels, MD Fallin… - Annual review of …, 2017 - annualreviews.org
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with lifelong
impacts. Genetic and environmental factors contribute to ASD etiology, which remains …

Emerging roles for the gut microbiome in autism spectrum disorder

HE Vuong, EY Hsiao - Biological psychiatry, 2017 - Elsevier
Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder that affects one
in 45 children in the United States, with a similarly striking prevalence in countries around …

[HTML][HTML] The role of the immune system in autism spectrum disorder

A Meltzer, J Van de Water - Neuropsychopharmacology, 2017 - nature.com
Autism is a neurodevelopmental disorder characterized by deficits in communication and
social skills as well as repetitive and stereotypical behaviors. While much effort has focused …

[PDF][PDF] Genomic patterns of de novo mutation in simplex autism

TN Turner, BP Coe, DE Dickel, K Hoekzema… - Cell, 2017 - cell.com
To further our understanding of the genetic etiology of autism, we generated and analyzed
genome sequence data from 516 idiopathic autism families (2,064 individuals). This …

[HTML][HTML] A multi-network approach identifies protein-specific co-expression in asymptomatic and symptomatic Alzheimer's disease

NT Seyfried, EB Dammer, V Swarup, D Nandakumar… - Cell systems, 2017 - cell.com
Here, we report proteomic analyses of 129 human cortical tissues to define changes
associated with the asymptomatic and symptomatic stages of Alzheimer's disease (AD) …

Altered proliferation and networks in neural cells derived from idiopathic autistic individuals

MC Marchetto, H Belinson, Y Tian, BC Freitas… - Molecular …, 2017 - nature.com
Autism spectrum disorders (ASD) are common, complex and heterogeneous
neurodevelopmental disorders. Cellular and molecular mechanisms responsible for ASD …

Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders

U Neniskyte, CT Gross - Nature Reviews Neuroscience, 2017 - nature.com
The final stage of brain development is associated with the generation and maturation of
neuronal synapses. However, the same period is also associated with a peak in synapse …

Neuroimmunology and neuroepigenetics in the establishment of sex differences in the brain

MM McCarthy, BM Nugent, KM Lenz - Nature Reviews Neuroscience, 2017 - nature.com
The study of sex differences in the brain is a topic of neuroscientific study that has broad
reaching implications for culture, society and biomedical science. Recent research in rodent …