Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and
predictor of a range of morbidities and all-cause mortality. To investigate the genetic …

Mendelian randomization uses genetic variants to make causal inferences about the effect
of a risk factor on an outcome. With fine‐mapped genetic data, there may be hundreds of …

Autism spectrum disorder is a developmental condition of early childhood onset, which
impacts socio-communicative functioning and is principally genetic in etiology. Currently …

Almost all species show sexual discordance in many traits and diseases. DNA methylation is
known to contribute to these differences through well-established mechanisms including X …

Abstract Background Estrone (E1), the major circulating estrogen in postmenopausal
women, promotes estrogen-receptor positive (ER+) breast tumor growth and proliferation …

The objective of this study is to find single nucleotide polymorphisms (SNPs) associated with
a risk of Type 2 diabetes (T2D) in Korean adults and to investigate the longitudinal …

Context: Testosterone (T) is a central androgenic hormone, and sex hormone-binding
globulin (SHBG) is the major determinant of its bioactivity. There are no acknowledged …

Sex influences the risk of most common diseases that affect both men and women. The goal
of this work has been to present the existing evidence in humans about the interplay …

JMJD1C, a member of the Jumonji-domain containing histone demethylases protein family,
has been associated with levels of sex-hormone binding globulin (SHBG) and testosterone …