[HTML][HTML] Initiation and execution mechanisms of necroptosis: an overview
S Grootjans, T Vanden Berghe… - Cell Death & …, 2017 - nature.com
Necroptosis is a form of regulated cell death, which is induced by ligand binding to TNF
family death domain receptors, pattern recognizing receptors and virus sensors. The …
family death domain receptors, pattern recognizing receptors and virus sensors. The …
Necroptotic cell death in anti‐cancer therapy
Necroptosis is one the best‐characterized forms of regulated necrosis. Necroptosis is
mediated by the kinase activities of receptor interacting protein kinase‐1 and receptor …
mediated by the kinase activities of receptor interacting protein kinase‐1 and receptor …
MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis
S Liu, H Liu, A Johnston… - Proceedings of the …, 2017 - National Acad Sciences
Mixed-lineage kinase domain-like protein (MLKL) is essential for TNF-α–induced
necroptosis. How MLKL promotes cell death is still under debate. Here we report that MLKL …
necroptosis. How MLKL promotes cell death is still under debate. Here we report that MLKL …
[HTML][HTML] Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis
E Reynoso, H Liu, L Li, AL Yuan, S Chen… - Journal of Biological …, 2017 - ASBMB
Necroptosis is an immunogenic cell death program that is associated with a host of human
diseases, including inflammation, infections, and cancer. Receptor-interacting protein kinase …
diseases, including inflammation, infections, and cancer. Receptor-interacting protein kinase …
Tümör nekroz faktörü reseptör 1'in (TNFR1) sinyal iletim mekanizmasının araştırılması
FZ Hapil - 2017 - dspace.akdeniz.edu.tr
TNF-α, birçok farklı etki gösteren bir sitokin olup, etkilerinin çoğunu TNFR1 sayesinde
sağlamaktadır. TNF-α aracılı NF-κB aktivasyonu, kaspaz aktivasyonu ve nekroptoz …
sağlamaktadır. TNF-α aracılı NF-κB aktivasyonu, kaspaz aktivasyonu ve nekroptoz …