There is highly credible evidence that melatonin mitigates cancer at the initiation,
progression and metastasis phases. In many cases, the molecular mechanisms …

DNA repair is responsible for maintaining the integrity of the genome. Perturbations in the
DNA repair pathways have been identified in several human cancers. Thus, compounds …

DNA damage/repair constitutes several key pathways working in concert to eliminate DNA
lesions and maintain genome stability and integrity. Defective components in DNA damage …

Purpose The present study is to discover a new genes associated with drug resistance
development in ovarian cancer. Methods We used microarray analysis to determine …

Worsening air pollution is a serious threat to public health in many urban and heavily
industrialized areas. Particle size and chemical composition are well known determinants of …

The significant role of the immune system in cancer treatment has given rise to an emerging
field of study within oncology, and one that is attracting increasing attention from …

Hepatocellular carcinoma (HCC) is one of the top three cancer killers worldwide. To identify
CNV-driven differentially expressed genes (DEGs) in HBV related HCC, this study integrated …

Abstract A Pt (IV) prodrug, Cx-platin, containing CX-4945 (a CK2 inhibitor) as an axial ligand
was designed and prepared by targeting CK2 to disrupt DNA damage response. In vitro …

Colitis associated cancer (CAC) is chronic inflammation driven colon cancer, prevalent
among individuals with Inflammatory Bowel Disease. Matrix-metalloproteinase (MMP9) is …

Recent work directed toward understanding the molecular features of advanced prostate
cancers has revealed a relatively high incidence of both germline and somatic alterations in …