Inflammaging and 'Garb-aging'

C Franceschi, P Garagnani, G Vitale, M Capri… - Trends in Endocrinology …, 2017 - cell.com
'Inflammaging'refers to the chronic, low-grade inflammation that characterizes aging.
Inflammaging is macrophage centered, involves several tissues and organs, including the …

[HTML][HTML] Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition

PC Calder, N Bosco, R Bourdet-Sicard, L Capuron… - Ageing research …, 2017 - Elsevier
Ageing of the global population has become a public health concern with an important socio-
economic dimension. Ageing is characterized by an increase in the concentration of …

Caloric restriction improves health and survival of rhesus monkeys

JA Mattison, RJ Colman, TM Beasley, DB Allison… - Nature …, 2017 - nature.com
Caloric restriction (CR) without malnutrition extends lifespan and delays the onset of age-
related disorders in most species but its impact in nonhuman primates has been …

Sleep health: reciprocal regulation of sleep and innate immunity

MR Irwin, MR Opp - Neuropsychopharmacology, 2017 - nature.com
Sleep disturbances including insomnia independently contribute to risk of inflammatory
disorders and major depressive disorder. This review and overview provides an integrated …

The mitochondrial basis of aging and age-related disorders

S Srivastava - Genes, 2017 - mdpi.com
Aging is a natural phenomenon characterized by progressive decline in tissue and organ
function leading to increased risk of disease and mortality. Among diverse factors that …

[HTML][HTML] 3D inkjet printing of tablets exploiting bespoke complex geometries for controlled and tuneable drug release

M Kyobula, A Adedeji, MR Alexander, E Saleh… - Journal of Controlled …, 2017 - Elsevier
A hot melt 3D inkjet printing method with the potential to manufacture formulations in
complex and adaptable geometries for the controlled loading and release of medicines is …

The UPRER: sensor and coordinator of organismal homeostasis

AE Frakes, A Dillin - Molecular cell, 2017 - cell.com
Life is stressful. Organisms are repeatedly exposed to stressors that disrupt protein
homeostasis (proteostasis), resulting in protein misfolding and aggregation. To sense and …

Wine flavonoids in health and disease prevention

I Fernandes, R Pérez-Gregorio, S Soares, N Mateus… - Molecules, 2017 - mdpi.com
Wine, and particularly red wine, is a beverage with a great chemical complexity that is in
continuous evolution. Chemically, wine is a hydroalcoholic solution (~ 78% water) that …

Senescence in COPD and its comorbidities

PJ Barnes - Annual review of physiology, 2017 - annualreviews.org
Chronic obstructive pulmonary disease (COPD) is regarded as a disease of accelerated
lung aging. This affliction shows all of the hallmarks of aging, including telomere shortening …

[HTML][HTML] Human longevity: 25 genetic loci associated in 389,166 UK biobank participants

LC Pilling, CL Kuo, K Sicinski, J Tamosauskaite… - Aging (Albany …, 2017 - ncbi.nlm.nih.gov
We undertook a genome-wide association study (GWAS) of parental longevity in European
descent UK Biobank participants. For combined mothers' and fathers' attained age, 10 loci …