Advances in the sequencing and the analysis of the genomes of both modern and ancient
peoples have facilitated a number of breakthroughs in our understanding of human …

Until the mid-1980s studies of steroidogenesis largely depended on identifying steroid
structures and measuring steroid concentrations in body fluids. The molecular biology …

The vast majority of genome-wide association studies (GWASs) are performed in
Europeans, and their transferability to other populations is dependent on many factors (eg …

We assembled genome-wide data from 16 prehistoric Africans. We show that the anciently
divergent lineage that comprises the primary ancestry of the southern African San had a …

INTRODUCTION Variation in pigmentation among human populations may reflect local
adaptation to regional light environments, because dark skin is more photoprotective …

Bantu languages are spoken by about 310 million Africans, yet the genetic history of Bantu-
speaking populations remains largely unexplored. We generated genomic data for 1318 …

Abstract Background Polygenic risk scores (PRSs) have successfully summarized genome-
wide effects of genetic variants in schizophrenia with significant predictive power. In a …

Approximately 15 genes have been directly associated with skin pigmentation variation in
humans, leading to its characterization as a relatively simple trait. However, by assembling a …

Population stratification (PS) is a primary consideration in studies of genetic determinants of
human traits. Failure to control for PS may lead to confounding, causing a study to fail for …

New discoveries and dating of fossil remains from the Rising Star cave system, Cradle of
Humankind, South Africa, have strong implications for our understanding of Pleistocene …