Check point inhibitors as therapies for infectious diseases
MA Cox, R Nechanitzky, TW Mak - Current Opinion in Immunology, 2017 - Elsevier
Highlights•Immune cells combating chronic infection express numerous 'check
point'receptors in human patients.•Inhibition of these receptors restores the function of …
point'receptors in human patients.•Inhibition of these receptors restores the function of …
Structure properties and mechanisms of action of naturally originated phenolic acids and their derivatives against human viral infections
YH Wu, BY Zhang, LP Qiu, RF Guan… - Current medicinal …, 2017 - ingentaconnect.com
Background: A great effort has been made to develop efficacious antiviral drugs, but many
viral infections are still lack of efficient antiviral therapies so far. The related exploration of …
viral infections are still lack of efficient antiviral therapies so far. The related exploration of …
NLRX1 mediates MAVS degradation to attenuate the hepatitis C virus-induced innate immune response through PCBP2
Y Qin, B Xue, C Liu, X Wang, R Tian, Q Xie… - Journal of …, 2017 - Am Soc Microbiol
Activation of innate immunity is essential for host cells to restrict the spread of invading
viruses and other pathogens. However, attenuation or termination of signaling is also …
viruses and other pathogens. However, attenuation or termination of signaling is also …
Healthcare contact and treatment uptake following hepatitis C virus screening and counseling among rural Appalachian people who use drugs
DB Stephens, AM Young, JR Havens - International Journal of Drug Policy, 2017 - Elsevier
Abstract Background Hepatitis C virus (HCV) remains a major contributor to morbidity and
mortality worldwide. Since 2009, Kentucky has led the United States in cases of acute HCV …
mortality worldwide. Since 2009, Kentucky has led the United States in cases of acute HCV …
Interaction between Galectin-9/TIM-3 pathway and follicular helper CD4+ T cells contributes to viral persistence in chronic hepatitis C
Y Zhuo, YF Zhang, HJ Wu, L Qin, YP Wang… - Biomedicine & …, 2017 - Elsevier
Abstract Both Galectin 9 (Gal-9)/T-cell immunoglobulin and mucin domain-containing
protein 3 (TIM-3) pathway and follicular helper CD4+ T (Tfh) cells play important roles in …
protein 3 (TIM-3) pathway and follicular helper CD4+ T (Tfh) cells play important roles in …
Inhibitors of Yellow Fever Virus replication based on 1, 3, 5-triphenyl-4, 5-dihydropyrazole scaffold: design, synthesis and antiviral evaluation
R Fioravanti, N Desideri, A Carta, EM Atzori… - European Journal of …, 2017 - Elsevier
By the antiviral screening of an in house library of pyrazoline compounds, 4-(3-(4-
phenoxyphenyl)-5-phenyl-4, 5-dihydro-1H-pyrazol-1-yl) benzenesulfonamide (5a) was …
phenoxyphenyl)-5-phenyl-4, 5-dihydro-1H-pyrazol-1-yl) benzenesulfonamide (5a) was …
Avasimibe: A novel hepatitis C virus inhibitor that targets the assembly of infectious viral particles
L Hu, J Li, H Cai, W Yao, J Xiao, YP Li, X Qiu, H Xia… - Antiviral Research, 2017 - Elsevier
Abstract Direct-acting antivirals (DAAs), which target hepatitis C virus (HCV) proteins, have
exhibited impressive efficacy in the management of chronic hepatitis C. However, the …
exhibited impressive efficacy in the management of chronic hepatitis C. However, the …
Highlights of the 30th international conference on antiviral research
Abstract The 30th International Conference on Antiviral Research (ICAR) was held in
Atlanta, GA, USA from May 18 to 21, 2017. This report provides an account of award …
Atlanta, GA, USA from May 18 to 21, 2017. This report provides an account of award …
[HTML][HTML] Efficacy and safety of combined directly acting antivirals for treatment of Chinese chronic hepatitis C patients in a real-world setting
JH Chen, Z Zeng, XX Zhang, Y Zhang… - World Journal of …, 2017 - ncbi.nlm.nih.gov
AIM To assess the efficacy and safety of combined directly acting antivirals (DAAs) for the
treatment of Chinese chronic hepatitis C (CHC) patients in a real-world setting. METHODS …
treatment of Chinese chronic hepatitis C (CHC) patients in a real-world setting. METHODS …
Immunology taught by rats
P Klenerman, EJ Barnes - Science, 2017 - science.org
Immunology may be best taught by viruses (1), and possibly by humans (2), but the rats of
New York City surprisingly also have plenty to offer. A survey published in 2014 of the …
New York City surprisingly also have plenty to offer. A survey published in 2014 of the …