Organisms throughout biology need to maintain the integrity of their genome. From bacteria
to vertebrates, life has established sophisticated mechanisms to detect and eliminate foreign …

Interferonopathies comprise an expanding group of monogenic diseases characterised by
disturbance of the homeostatic control of interferon (IFN)-mediated immune responses …

An unresolved question is how HIV‐1 achieves efficient replication in terminally
differentiated macrophages despite the restriction factor SAMHD 1. We reveal inducible …

SAMHD1 hydrolyzes 2'-deoxynucleoside-5'-triphosphates (dNTPs) into 2'-deoxynucleosides
and inorganic triphosphate products. In this paper, we evaluated the impact of 2'sugar …

The enzyme, sterile α motif and histidine‐aspartic acid domain–containing protein 1
(SAMHD1) diminishes infection of human immunodeficiency virus type 1 (HIV‐1) by …

In this study, we report that the tetraspanin CD81 enhances human immunodeficiency virus
(HIV)-1 reverse transcription in HIV-1-infected cells. This is enabled by the direct interaction …

Mutations in the human SAMHD1 gene are known to correlate with the development of the
Aicardi–Goutières syndrome (AGS), which is an inflammatory encephalopathy that exhibits …

The innate immune response constitutes the first cellular line of defense against initial HIV-1
infection. Immune cells sense invading virus and trigger signaling cascades that induce …

Sterile α motif and HD domain-containing protein 1 (SAMHD1) is a mammalian dNTP
hydrolase (dNTPase) that regulates intracellular dNTP balance. We have previously …

The triphosphohydrolase SAMHD1 (sterile α motif and histidine-aspartate domain-
containing protein 1) restricts HIV-1 replication in nondividing myeloid cells by depleting the …