Biological aging is characterized by a chronic low-grade inflammation level. This chronic
phenomenon has been named “inflamm-aging” and is a highly significant risk factor for …

The number of people over the age of 60 is expected to double by 2050 according to the
WHO. This emphasizes the need to ensure optimized resilience to health stressors in late …

Cytomegalovirus (CMV) is an important pathogen for both clinical and population settings.
There is a growing body of research implicating CMV in multiple health outcomes across the …

A number of biological parameters have been cited as hallmarks of immune aging.
However, it is not clear whether these multiple biological changes are the result of common …

Cytomegalovirus (CMV) has been described as a contributor to immunosenescence, thus
exacerbating age-related diseases. In persons with latent CMV infection, the CD8+ T cell …

CD4+ T cells are essential for human CMV infection control. CMV-specific CD4+ T cells
possess antiviral functions and participate in anti-CMV humoral/cellular responses. In the …

Like all somatic tissues, the human immune system changes with age. This is believed to
result in an increased frequency of, and susceptibility to, infectious disease and to contribute …

Background Numbers of blood leukocyte subsets are highly dynamic in childhood and differ
greatly between subjects. Interindividual variation is only partly accounted for by genetic …

Poor CD4+ T-cell recovery after cART has been associated with skewed T-cell maturation,
inflammation and immunosenescence; however, T-cell functionality in those individuals has …

BK polyomavirus (BKPyV) reactivation in kidney transplant recipients can lead to allograft
damage and loss. The elements of the adaptive immune system that are permissive of …