Individuals age> 65 years old are the fastest expanding population demographic throughout
the developed world. Consequently, more aged patients than before are receiving …

Mistakes during cell division frequently generate changes in chromosome content,
producing aneuploid or polyploid progeny cells. Polyploid cells may then undergo abnormal …

Aneuploidy, a state of karyotype imbalance, is a hallmark of cancer. Changes in
chromosome copy number have been proposed to drive disease by modulating the dosage …

Aneuploidy is a hallmark of cancer, although its effects on tumorigenesis are unclear. Here,
we investigated the relationship between aneuploidy and cancer development using cells …

Defining the genes that are essential for cellular proliferation is critical for understanding
organismal development and identifying high-value targets for disease therapies. However …

Studying the phenomenon of cellular senescence has been hindered by the lack of
senescence-specific markers. As such, detection of proteins informally associated with …

With aging, there is progressive loss of tissue homeostasis and functional reserve, leading to
an impaired response to stress and an increased risk of morbidity and mortality. A key …

Aneuploidy, the state of having gained or lost chromosomes, is a hallmark of cancer.
Approximately 90% of tumors have gained or lost at least one chromosome. In spite of …

Chromosome instability (CIN) is deleterious to normal cells because of the burden of
aneuploidy. However, most human solid tumors have an abnormal karyotype implying that …

The growing burden of obesity-and aging-related diseases has hastened the search for
governing biological processes. Cellular senescence is a stress-induced state of stable …