Human genetic studies into rheumatoid arthritis (RA) have uncovered more than 100 genetic
loci associated with susceptibility to RA and have refined the RA-association model for HLA …

Primary sclerosing cholangitis (PSC) is a chronic disease leading to fibrotic scarring of the
intrahepatic and extrahepatic bile ducts, causing considerable morbidity and mortality via …

HLA class I glycoproteins contain the functional sites that bind peptide antigens and engage
lymphocyte receptors. Recently, clinical application of sequence-based HLA typing has …

The major histocompatibility complex system is the most polymorphic gene cluster of the
mammal genome. In humans, this is a genomic locus known as the human leukocyte …

The major histocompatibility complex (MHC) is located in chromosome 6p21 and contains
crucial regulators of immune response, including human leucocyte antigen (HLA) genes …

Although many phenotypes have been associated with variants in human leukocyte antigen
(HLA) genes, the full phenotypic impact of HLA variants across all diseases is unknown. We …

The most polymorphic part of the human genome, the MHC, encodes over 160 proteins of
diverse function. Half of them, including the HLA class I and II genes, are directly involved in …

When considering HLA-matched hematopoietic cell transplantation (HCT), sibling and
unrelated donors (UDs) are biologically different because UD-HCT is typically performed …

Idiopathic membranous nephropathy (MN) is associated with HLA; however, the HLA allele
involved remains unknown. To identify the HLA risk alleles associated with phospholipase …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system,
characterized by focal inflammation, demyelination, and axonal injury. The etiology of MS is …