The biological fates of the key initiator of Alzheimer's disease (AD), the amyloid precursor
protein (APP), and a family of lipoprotein receptors, the low-density lipoprotein (LDL) …

This Review describes the current status of poststroke epilepsy (PSE) with an emphasis on
poststroke epileptogenesis modeling for testing new therapeutic agents. Stroke is a leading …

Aims Although changes in extracellular matrix (ECM) scaffold have been reported previously
in Alzheimer's disease (AD) compared to normal ageing, it is not known how alterations in …

The number of individuals suffering from diseases of the central nervous system (CNS) is
growing with an aging population. While candidate drugs for many of these diseases are …

In the past, the blood-brain barrier (BBB) has been characterized mainly as a layer of
endothelial cells forming the vessel/capillary wall of the brain. More recently, the BBB is …

Herein, we review innovative nanomedicine-based approaches for treating, preventing and
diagnosing neurodegenerative diseases. We focus on nanoscale systems such as …

The blood-brain barrier (BBB) is an important barrier that separates and protects the brain
from the peripheral circulation. This BBB is formed by special tight junctions, a feature of the …

Astrocytes have a well-developed cytoskeleton that is dominated by intermediate filaments
but also includes microtubules and actin filaments, consistent with a role as structural …