Biological age predictors

J Jylhävä, NL Pedersen, S Hägg - EBioMedicine, 2017 - thelancet.com
The search for reliable indicators of biological age, rather than chronological age, has been
ongoing for over three decades, and until recently, largely without success. Advances in the …

[HTML][HTML] Molecular and phenotypic biomarkers of aging

X Xia, W Chen, J McDermott, JDJ Han - F1000Research, 2017 - ncbi.nlm.nih.gov
Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging
are valuable tools to measure physiological age, assess the extent of 'healthy aging', and …

Are objective measures of physical capability related to accelerated epigenetic age? Findings from a British birth cohort

AJ Simpkin, R Cooper, LD Howe, CL Relton… - BMJ open, 2017 - bmjopen.bmj.com
Objectives Our aim was to investigate the association of epigenetic age and physical
capability in later life. Having a higher epigenetic than chronological age (known as age …

Individual CpG sites that are associated with age and life expectancy become hypomethylated upon aging

Y Zhang, J Hapala, H Brenner, W Wagner - Clinical epigenetics, 2017 - Springer
Background There is a growing interest in simple molecular biomarkers for biological aging.
Age-associated DNA methylation (DNAm) changes at specific CG dinucleotides can be …

Translating measures of biological aging to test effectiveness of geroprotective interventions: what can we learn from research on telomeres?

WJ Hastings, I Shalev, DW Belsky - Frontiers in Genetics, 2017 - frontiersin.org
Intervention studies in animals suggest molecular changes underlying age-related disease
and disability can be slowed or reversed. To speed translation of these so-called …