Highlights•Convergence between axon regeneration ability and abnormal synaptic structure
and function.•Axon regeneration, neuronal circuit assembly and recovery of functions in the …

In the adult mammalian central nervous system (CNS), neurons typically fail to regenerate
their axons after injury. During development, by contrast, neurons extend axons effectively. A …

At least 30 types of retinal ganglion cells (RGCs) send distinct messages through the optic
nerve to the brain. Available strategies of promoting axon regeneration act on only some of …

After nerve injury, Schwann cells convert to a phenotype specialized to promote repair. But
during the slow process of axonal regrowth, these repair Schwann cells gradually lose their …

Functional deficits persist after spinal cord injury (SCI) because axons in the adult
mammalian central nervous system (CNS) fail to regenerate. However, modest levels of …

Damaged central nervous system (CNS) neurons have a poor ability to spontaneously
regenerate, causing persistent functional deficits after injury. Therapies that stimulate axon …

Friedreich's ataxia (FRDA), the most common inherited ataxia, is caused by recessive
mutations that reduce the levels of frataxin (FXN), a mitochondrial iron binding protein. We …

Wallerian degeneration is an active program tightly associated with axonal degeneration,
required for axonal regeneration and functional recovery after nerve damage. Here we …

In contrast to central nervous system neurons, dorsal root ganglia (DRG) neurons can switch
to a regenerative state after peripheral axotomy. In a screen for chromatin regulators of the …

Neuropathic pain is maladaptive pain caused by injury or dysfunction in peripheral and
central nervous system, and remains a worldwide thorny problem leading to decreases in …