Dissecting the genetics of complex traits using summary association statistics

B Pasaniuc, AL Price - Nature reviews genetics, 2017 - nature.com
During the past decade, genome-wide association studies (GWAS) have been used to
successfully identify tens of thousands of genetic variants associated with complex traits and …

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci

D Chang, MA Nalls, IB Hallgrímsdóttir, J Hunkapiller… - Nature …, 2017 - nature.com
Common variant genome-wide association studies (GWASs) have, to date, identified> 24
risk loci for Parkinson's disease (PD). To discover additional loci, we carried out a GWAS …

Prospects of fine-mapping trait-associated genomic regions by using summary statistics from genome-wide association studies

C Benner, AS Havulinna, MR Järvelin… - The American Journal of …, 2017 - cell.com
During the past few years, various novel statistical methods have been developed for fine-
mapping with the use of summary statistics from genome-wide association studies (GWASs) …

Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution

R Mägi, M Horikoshi, T Sofer, A Mahajan… - Human molecular …, 2017 - academic.oup.com
Trans-ethnic meta-analysis of genome-wide association studies (GWAS) across diverse
populations can increase power to detect complex trait loci when the underlying causal …

Integrating molecular QTL data into genome-wide genetic association analysis: Probabilistic assessment of enrichment and colocalization

X Wen, R Pique-Regi, F Luca - PLoS genetics, 2017 - journals.plos.org
We propose a novel statistical framework for integrating the result from molecular
quantitative trait loci (QTL) mapping into genome-wide genetic association analysis of …

Mendelian randomization with fine‐mapped genetic data: choosing from large numbers of correlated instrumental variables

S Burgess, V Zuber, E Valdes‐Marquez… - Genetic …, 2017 - Wiley Online Library
Mendelian randomization uses genetic variants to make causal inferences about the effect
of a risk factor on an outcome. With fine‐mapped genetic data, there may be hundreds of …

[HTML][HTML] Bayesian large-scale multiple regression with summary statistics from genome-wide association studies

X Zhu, M Stephens - The annals of applied statistics, 2017 - ncbi.nlm.nih.gov
Bayesian methods for large-scale multiple regression provide attractive approaches to the
analysis of genome-wide association studies (GWAS). For example, they can estimate …

Large-scale cognitive GWAS meta-analysis reveals tissue-specific neural expression and potential nootropic drug targets

M Lam, JW Trampush, J Yu, E Knowles, G Davies… - Cell reports, 2017 - cell.com
Here, we present a large (n= 107,207) genome-wide association study (GWAS) of general
cognitive ability (" g"), further enhanced by combining results with a large-scale GWAS of …

Whole-genome sequencing coupled to imputation discovers genetic signals for anthropometric traits

I Tachmazidou, D Süveges, JL Min, GRS Ritchie… - The American Journal of …, 2017 - cell.com
Deep sequence-based imputation can enhance the discovery power of genome-wide
association studies by assessing previously unexplored variation across the common-and …

Improved methods for multi-trait fine mapping of pleiotropic risk loci

G Kichaev, M Roytman, R Johnson, E Eskin… - …, 2017 - academic.oup.com
Motivation Genome-wide association studies (GWAS) have identified thousands of regions
in the genome that contain genetic variants that increase risk for complex traits and …