When the immune system responds to tumour development, patterns of immune infiltrates
emerge, highlighted by the expression of immune checkpoint-related molecules such as …

This review presents a brief overview of breast cancer, focussing on its heterogeneity and
the role of mathematical modelling and simulation in teasing apart the underlying …

Background Triple-negative breast cancer lacks estrogen, progesterone, and HER2
receptors and is thus not possible to treat with targeted therapies for these receptors …

Physical oncology has the potential to revolutionize cancer research and treatment. The
fundamental rationale behind this approach is that physical processes, such as transport …

Epigenetic and genetic alterations are two mechanisms participating in leukemia, which can
inactivate genes involved in leukemia pathogenesis or progression. The purpose of this …

Background Understanding cancer development crossing several spatial-temporal scales is
of great practical significance to better understand and treat cancers. It is difficult to tackle …

Spatial models of vascularized tissues are widely used in computational physiology. We
introduce a software library for composing multiscale, multiphysics models for applications …

When Seeing Isn't Believing: How Math Can Guide Our Interpretation of Measurements and
Experiments: Cell Systems Skip to Main Content Skip to Main Menu Advertisement Cell Systems …

This paper aims at modeling breast cancer transition from the in situ stage–when the tumor
is confined to the duct–to the invasive phase. Such a transition occurs thanks to the …

The heart rate variability is one of the most relevant health indicators. This indicator is
related with the survival after myocardial infarction, the capacity of self-regulating emotions …