Since the introduction of mental disorders as networks of causally interacting symptoms, this
novel framework has received considerable attention. The past years have resulted in over …

It is nearly 20 years since the concept of a small-world network was first quantitatively
defined, by a combination of high clustering and short path length; and about 10 years since …

Major depressive disorder (MDD) is a leading cause of disease burden worldwide. While the
incidence, symptoms and treatment of MDD all point toward major sex differences, the …

Although all human tissues carry out common processes, tissues are distinguished by gene
expression patterns, implying that distinct regulatory programs control tissue specificity. In …

A potentially useful approach for drug discovery is to connect gene expression profiles of
disease-affected tissues (“disease signatures”) to drug signatures, but it remains to be …

Progresses in mass spectrometric instrumentation and bioinformatics identification
algorithms made over the past decades allow quantitative measurements of relative or …

Improved analytical technologies and data extraction algorithms enable detection of> 10
000 reproducible signals by liquid chromatography–high-resolution mass spectrometry …

Objective Inadequate immunoregulation and elevated inflammation may be risk factors for
posttraumatic stress disorder (PTSD), and microbial inputs are important determinants of …

The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental
gene networks implicated in autism. We examined the impact of germline heterozygous …

Abstract Background Few long noncoding RNAs (lncRNAs) that act as oncogenic genes in
breast cancer have been identified. Methods Oncogenic lncRNAs associated with …