Cellular senescence is a state of stable proliferation arrest of cells. The senescence pathway
has many beneficial effects and is seen to be activated in damaged/stressed cells, as well as …

Multiple myeloma typically affects elderly patients. Approximately one-third of patients are
older than 75 years at diagnosis. Moreover, at least 30% are frail, both due to disease …

Senolytic drugs are agents that selectively induce apoptosis of senescent cells. These cells
accumulate in many tissues with aging and at sites of pathology in multiple chronic …

Senescent cells play important roles in both physiological and pathological processes,
including cancer and aging. In all cases, however, senescent cells comprise only a small …

Cellular senescence is now recognized as one of the nine hallmarks of ageing. Recent data
show the involvement of senescent cells in tissue ageing and some age-related diseases …

The epidermis is a self-renewing tissue. The balance between proliferation and
differentiation processes is tightly regulated to ensure the maintenance of the stem cell (SC) …

Background: Cognitive and physical impairment frequently co-occur in older people. The
aim of this study was to assess the temporal order of these age-related changes in cognitive …

Skin is constantly exposed to environmental factors such as pollutants, chemicals and ultra
violet radiation (UV), which can induce premature skin aging and increase the risk of skin …

Cellular senescence, which has been linked to age-related diseases, occurs during normal
aging or as a result of pathological cell stress. Due to their incapacity to proliferate …

In addition to measures already used in clinical practice, molecular measures have been
proposed to assess health status, but these have not yet been introduced into clinical …