The global overuse of antibiotics has led to the emergence of drug-resistant pathogenic
bacteria. Bacteria can combat β-lactams by expressing β-lactamases. Inhibitors of one class …

The efficacy of β-lactam antibiotics is threatened by the emergence and global spread of
metallo-β-lactamase (MBL) mediated resistance, specifically New Delhi metallo-β-lactamase …

There is urgent need for new therapeutic strategies to fight the global threat of antibiotic
resistance. The focus of this Perspective is on chemical agents that target the most common …

Bacterial resistance is compromising the use of β-lactam antibiotics including carbapenems.
The main resistance mechanism against β-lactams is hydrolysis of the β-lactam ring …

Pathogens, expressing metallo-β-lactamases (MBLs), become resistant against most β-
lactam antibiotics. Besides the dragging search for new antibiotics, development of MBL …

Multidrug-resistant bacterial infections have become in recent years an increasingly
worrisome problem in the medical community. The β-lactams are the most used antibiotics …

The inhibitory activity of captopril, a thiol-containing competitive inhibitor of the angiotensin-
converting enzyme, ACE, against esterase activity of carbonic anhydrase, CA was …

ABSTRACT Metallo-β-lactamases (MBLs) threaten the effectiveness of β-lactam antibiotics,
including carbapenems, and are a concern for global public health. β-Lactam/β-lactamase …

The rapid development of antimicrobial resistance over the past three decades represents a
critical public health threat and urgent challenge. In this context, in order to establish lead …

Many β-lactam drugs, including penicillins, monobactams cephalosporins, and
carbapenems, are used in clinical treatment of bacterial infections. However, resistant …