Genetic causes of functional adrenocortical adenomas

MC Zennaro, S Boulkroun… - Endocrine …, 2017 - academic.oup.com
Aldosterone and cortisol, the main mineralocorticoid and glucocorticoid hormones in
humans, are produced in the adrenal cortex, which is composed of three concentric zones …

Diagnosing endocrine hypertension: a practical approach

J Yang, J Shen, PJ Fuller - Nephrology, 2017 - Wiley Online Library
Hypertension is a leading cardiovascular risk factor that remains difficult to manage in a
large segment of the population. Secondary causes of hypertension, which are amenable to …

[HTML][HTML] Trial of amiloride in type 2 diabetes with proteinuria

ML Unruh, VS Pankratz, JE Demko, EC Ray… - Kidney international …, 2017 - Elsevier
Introduction Renal sodium (Na+) retention and extracellular fluid volume expansion are
hallmarks of nephrotic syndrome, which occurs even in the absence of activation of …

[HTML][HTML] The time has come for systematic screening for primary aldosteronism in all hypertensives

G Maiolino, LA Calò, GP Rossi - Journal of the American College of …, 2017 - jacc.org
The control of blood pressure worldwide is disappointing; hence, the Lancet Commission on
Arterial Hypertension identified the 9 key actions to combat this major risk factor and, for the …

Microalbuminuria and plasma aldosterone levels in nondiabetic treatment-naive patients with hypertension

C Catena, GL Colussi, F Martinis, M Novello… - Journal of …, 2017 - journals.lww.com
Objectives: Identification of factors that contribute to urinary albumin losses in hypertensive
nephropathy is crucial for prevention of renal deterioration. The aim of this study was to …

Lateralization index but not contralateral suppression at adrenal vein sampling predicts improvement in blood pressure after adrenalectomy for primary aldosteronism

M Tagawa, M Ghosn, H Wachtel, D Fraker… - Journal of human …, 2017 - nature.com
Adrenal vein sampling (AVS) is essential in differentiating unilateral from bilateral sources of
aldosterone excess in primary aldosteronism (PA). However, its ability to predict blood …

ACTH stimulation test and computed tomography are useful for differentiating the subtype of primary aldosteronism

A Moriya, M Yamamoto, S Kobayashi… - Endocrine …, 2017 - jstage.jst.go.jp
The diagnostic steps for primary aldosteronism (PA) include case screening tests,
confirmatory tests, and localization. The aim of this study was to identify useful confirmatory …

[HTML][HTML] Body mass index and contralateral ratio predict outcome following unilateral adrenalectomy in primary aldosteronism

K Bokuda, M Yatabe, Y Mizuguchi, M Niiyama… - Hypertension …, 2017 - nature.com
The effect of unilateral adrenalectomy on blood pressure (BP) outcome in primary
aldosteronism (PA) is diverse. Therefore, we sought to investigate the preoperative factors …

Clinical characteristics and long-term outcome of primary aldosteronism in a Norwegian population

MA Grytaas, SS Strømsøy, JT Rørvik… - Hormone and …, 2017 - thieme-connect.com
Primary aldosteronism (PA) is the most common cause of secondary hypertension (HT). We
describe here clinical characteristics, diagnostic procedures, and long-term outcomes in a …

The potential role of primary care in case detection/screening of primary aldosteronism

GA Kline, APH Prebtani, AA Leung… - American Journal of …, 2017 - academic.oup.com
Endocrine hypertension, particularly primary aldosteronism (PA), was previously considered
to account for less than 1% of all hypertension and was suspected only when patients …